http://www.minifinity.com/forum/viewtopic.php?t=54195 Web25 de jun. de 2010 · The SIRT1 deacetylase and the HIF-1alpha transcription factor act as redox and oxygen sensors, respectively. Here, we found that SIRT1 binds to HIF-1alpha and deacetylates it at Lys674, ... 2010 Jun 25;38(6):864-78. …
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WebPaclitaxel treatment markedly increased HIF-1α and HIF-2α (Fig. 4A) as well as IL-6 (Fig. 4B) protein levels and significantly increased the percentage of ALDH + cells (Fig. 4C) in the NTC subclone, whereas neither HIF-1α, HIF-2α, nor IL-6 expression was induced and ALDH + cells were markedly reduced in the DKD subclone, both before and after treatment with … WebSeveral preclinical studies have suggested a potential benefit of HIF activation in myocardial infarction, cardiac remodeling, atherosclerosis, and peripheral artery disease. … simple wall firewall
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