WebFor instance, a few strains of highly inbred animals may be best for identifying the function of a specific gene, while a highly outbred population that captures much of the natural … WebInbred mice are also extremely small compared with outbred mice (average weights of 70-day-old males: inbred, 25.4 g; outbred, 34.7 g) 7.

The Importance of Genetic Background in Mouse Models

WebInbred mice are somewhat like identical twins, except that instead of just two, there can be many, many of them. Outbred mice are somewhat like the human population, with … WebDiversity Outbred mice were generated by breeding eight founder inbred strains together to produce a population with a random assortment of genetics (Figure 2). The eight founder strains were chosen specifically because of their unique characteristics. For example, one develops type 1 diabetes (NOD/ShiLtJ), another is prone to cancer (A/J), and ... grand old man of philippine arts

Inbred Versus Outbred Strains Center for Mouse Genome …

WebJan 1, 1994 · The inbred strain types are characterized by a high isogenicity - the strain members are genetically identical and homozygous at almost all loci (possibly with a forced heterozygosity at a single locus). The genotype of an inbred strain arises from an accidental fixation of alleles from the heterogeneous starting-population, so the animals of an inbred … Web보통 inbred와 outbred mouse는 실험실에서 많이 사용되고있는데 ICR과 B6의 차이는 알겠는데요 그럼 ICR은 유전적으로 이질성이 높고 B6는 유전적으로 같은데 실험에 … WebInbred mice are preferred over outbred mice with the assumption that they display less trait variability. We compared coefficients of variation and failed to find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice may be better subjects for most biomedical research. chinese in headington oxford