Phospholipase a2 receptor antibody pla2r
WebAnti-phospholipase A2 receptor antibody (anti-PLA2R) has emerged as a reliable biomarker for diagnosis, monitoring of disease activity and response to therapy in primary MN. … WebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN.
Phospholipase a2 receptor antibody pla2r
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WebPhospholipases A 2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A 2. Other families include Ca 2+ independent PLA2 (iPLA2) and lipoprotein-associated PLA2s (lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH). WebIn 2009, Beck et al 2 first discovered that the extracellular domain of phospholipase A2 receptor (PLA2R) was used as the mutant antigen to activate autoimmunity response. …
WebMar 5, 2015 · Hoxha, E. et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 82, 797–804 (2012). WebBackground: The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The effects of anti-PLA2R antibodies directly to the podocytes remain unclear.
WebSep 18, 2024 · Serum anti-phospholipase A2 receptor (PLA2R) antibody detected at diagnosis as a predictor for clinical remission in patients with primary membranous nephropathy: a meta-analysis Yufeng Liang, Jianxin Wan, Yongping Chen & Yangbin Pan BMC Nephrology 20, Article number: 360 ( 2024 ) Cite this article 7470 Accesses 11 … WebPhospholipase A2 Receptor (PLA2R) Antibody Panel This test is used to differentiate primary membranous nephropathy from secondary membranous nephropathy, and …
WebAug 19, 2014 · Background The presence of antibodies against the M-type phospholipase A2 receptor (PLA2R-AB) is considered to be a promising serological diagnostic biomarker of idiopathic membranous nephropathy (iMN). However, controversy remains about the diagnostic accuracy of serum PLA2R-AB testing. Here, we performed a comprehensive …
WebAntibodies to the phospholipase A2 receptor (PLA2R) occur in 70% to 80% of patients. Less frequently (in up to 10%), antibodies against thrombospondin type-1 domain-containing … csw timesheetWebRecent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R).(1) There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression.(2) The presence of ... csw torbayWebAnti-PLA2R antibody [CL0474] (ab188028) Datasheet SDS Submit a review Submit a question References (2) Key features and details Mouse monoclonal [CL0474] to PLA2R Suitable for: IHC-P, WB, ICC Reacts with: Human Isotype: IgG1 You may also be interested in Primary Anti-Ext1 antibody (ab126305) Peptide PLA2R peptide (ab176432) csw titleWebAbstract. Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy … cswtoWebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). csw toorop talent collegeWebbeck等 首次在成人imn患者血清中检测到抗m型磷脂酶a2受体(pla2r)的自身抗体，并发现抗体滴度与患者蛋白尿的消长相关，提示pla2r可能是imn的重要靶抗原。我们前期已针对血清pla2r抗体进行检测，发现病情缓解的imn患者血清学阳性率明显降低，提示单纯采用血 … cswtnorthadults trafford.gov.ukWebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy … earn me a point 23